Thompson, who is 65, received $300,000 in compensation from Merck in 2017, according to company financial filings. (2020). Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism.
Craig B. Thompson, MD President and CEO, Memorial Sloan Kettering Cancer Center The Thompson laboratory has proposed that the basis of metazoan cell survival is determined by the inability of cells to take up nutrients in a cell-autonomous fashion. He received clinical training in internal medicine at Harvard Medical School and in medical oncology at the Fred Hutchinson Cancer Research Center at the University of Washington.
Craig Thompson resigns from two corporate boards as MSK crisis shifts to board roles. , Thompson holds more than 30 patents related to immunotherapy and apoptosis, and is a founder of three biotechnology companies. Research Overview Featured News Publications The Craig Thompson Lab: Lab Members. At another meeting, reserved for medical staff members, some doctors said they were interested in calling a no-confidence vote in the hospital’s top leaders, and asked what steps they needed to take to do that, according to several participants in the meeting. (2020). … He has been on the board of Charles River Laboratories, a publicly traded company that assists research in early drug development, since 2013. , Thompson’s discovery of oncogenic metabolites (succinate, fumarate, and 2-hydroxyglutarate) that can inhibit tumor suppressor function and/or impair cellular differentiation has helped lead to the development of new treatments for leukemia, gliomas, sarcomas, and bladder cancer, currently in clinical trials. His discoveries in growth factor regulation of nutrient uptake and metabolism have provided direct mechanistic links between cellular metabolism and cell growth and survival. Thompson has studied how genes regulate apoptosis and metabolism, and investigated their application in treating cancer. The University of Pennsylvania filed the suit against Dr. Craig B. Thompson, claiming he improperly used research done at the university to start a pharmaceutical company.
Schwörer, S., Berisa, M., Violante, S., Qin, W., Zhu, J., Hendrickson, R. C., Cross, J. R., & Thompson, C. B.
Dr. Thompson’s decision to leave two boards does not affect the eight other Memorial Sloan Kettering officials who serve on the boards of outside companies. Proline biosynthesis is a vent for TGFβ-induced mitochondrial redox stress. The compensation for the two corporate boards is in addition to what he is paid as chief executive at Memorial Sloan Kettering, the nonprofit institution that is one of the nation's leading cancer centers. At one meeting with hospital staff, Dr. Thompson apologized for his handling of staff reaction to the issues outlined in the articles, and acknowledged that he had not adequately reined in the industry relationships of the hospital’s former chief medical officer, Dr. José Baselga, who has since resigned.
Laboratory Member. Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. This hypothesis was formulated to explain how multicellularity might have arisen during evolution. Charles Ornstein is a senior editor at ProPublica. This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). A., Xiao, Y., Melemenidis, S., Zhou, Y., Liu, L., Vanharanta, S., Graves, E. E., Rankin, E. B., Curtis, C., Massagué, J., Rabinowitz, J. D., Thompson, C. B., & Ye, J. Craig B. Thompson, chief executive of Memorial Sloan Kettering Cancer Center, will no longer serve on the board of drug maker Merck.
“The steps that have been made and taken since the meeting by our leadership have addressed the most important concerns to the medical staff and the associate medical staff and really represents a real progress.”, In addition to resigning his board positions, Dr. Thompson also said Tuesday that Memorial Sloan Kettering would give physicians a greater voice in its operations and would conduct an analysis to understand what had gone wrong at the hospital in recent weeks “so that we ensure our path forward is expertly guided by what we learn.”. His contributions demonstrate why it is so important to have leaders from the medical community represented on the board.”. (2020). This work has contributed to the resurgent interest in cancer cell metabolism and may form the basis for translational therapies to exploit the metabolic addictions exhibited by cancer cells. From 1993 until he joined the University of Pennsylvania, he was affiliated with the University of Chicago, where he was professor of medicine, a Howard Hughes investigator, and director of the Gwen Knapp Center for Lupus and Immunology Research. He was paid $70,000 in cash by Charles River in 2017, plus $215,050 in stock. Thompson identified the evolutionary duplication of CD28 into CD28 and CTLA-4 and demonstrated that CTLA4 had an inhibitory effect on immune activation. SOURCES: IRS Form 990, annual report or statement of individual nonprofit. Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. Postdoctoral Fellow.
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